And Cain went out from the presence of Jehovah, and dwelt in the land of Nod, toward the east of Eden.
And Cain knew his wife, and she conceived and bore Enoch. And he built a city; and he called the name of the city after the name of his son Enoch. And to Enoch was born Irad; and Irad begot Mehujael; and Mehujael begot Methushael; and Methushael begot Lemech.
Genesis 4 : 16 – 18 (Darby Translation)
“Cain cast off all fear of God, and attended no more on God’s ordinances.
Hypocritical professors, who dissemble and trifle with God, are justly left to themselves to do something grossly scandalous. So they throw off that form of godliness to which they have been a reproach, and of which they deny the power. Cain went out from the presence of the Lord, and we never find that he came into it again, to his comfort.
The land Cain dwelt in was called the land of Nod, which means, ‘shaking,’ or ‘trembling,’ and so shows the restlessness and uneasiness of his own spirit, or ‘the land of a vagabond:’ they that depart from God cannot find rest any where else.
Those on earth who looked for the heavenly city, chose to dwell in tabernacles or tents; but Cain, as not minding that city, built one on earth. Thus all who are cursed of God seek their settlement and satisfaction here below.”#
#Taken From Matthew Henry’s Concise Commentary.